Rhomboid protease GlpG

Details

Name
Rhomboid protease GlpG
Kind
protein
Synonyms
  • 3.4.21.105
  • Intramembrane serine protease
Gene Name
glpG
UniProtKB Entry
P44783Swiss-Prot
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
NCBI Taxonomy ID
71421
Amino acid sequence
>lcl|BSEQ0012990|Rhomboid protease GlpG
MKNFLAQQGKITLILTALCVLIYLAQQLGFEDDIMYLMHYPAYEEQDSEVWRYISHTLVH
LSNLHILFNLSWFFIFGGMIERTFGSVKLLMLYVVASAITGYVQNYVSGPAFFGLSGVVY
AVLGYVFIRDKLNHHLFDLPEGFFTMLLVGIALGFISPLFGVEMGNAAHISGLIVGLIWG
FIDSKLRKNSLE
Number of residues
192
Molecular Weight
21657.295
Theoretical pI
6.39
GO Classification
Functions
identical protein binding / serine-type endopeptidase activity
Components
integral component of membrane / plasma membrane
General Function
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
Specific Function
identical protein binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
11-31 58-78 83-103 108-128 142-162 164-184
Cellular Location
Cell inner membrane
Gene sequence
>lcl|BSEQ0012991|Rhomboid protease GlpG (glpG)
ATGAAAAACTTTTTAGCTCAACAAGGAAAAATCACGCTAATTCTCACCGCACTTTGTGTG
CTTATTTATCTTGCTCAACAGCTGGGTTTTGAAGACGATATTATGTATTTGATGCATTAC
CCCGCTTACGAAGAGCAAGATAGTGAAGTGTGGCGTTATATCTCACATACATTGGTACAT
TTATCTAATTTGCATATTTTGTTTAATCTGTCTTGGTTTTTTATTTTCGGTGGAATGATT
GAGCGCACTTTTGGCTCGGTTAAATTATTGATGTTGTATGTTGTAGCATCTGCCATAACA
GGATATGTGCAAAATTATGTGTCTGGCCCCGCTTTCTTTGGGCTTTCTGGTGTTGTATAT
GCGGTTCTAGGTTATGTATTTATACGTGATAAATTGAATCATCATTTATTTGATCTGCCA
GAAGGTTTTTTTACAATGTTATTGGTGGGGATCGCATTAGGTTTTATTAGCCCCTTATTT
GGTGTTGAAATGGGAAATGCTGCACATATTTCAGGCTTGATTGTCGGCTTGATTTGGGGA
TTTATTGATAGCAAATTGCGCAAAAATTCGCTAGAGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP44783
UniProtKB Entry NameGLPG_HAEIN
GenBank Protein ID3212176
GenBank Gene IDL42023
PDB ID(s)2NR9, 3ODJ
KEGG IDhin:HI0618
NCBI Gene ID950685
General References
  1. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]
  2. Lemieux MJ, Fischer SJ, Cherney MM, Bateman KS, James MN: The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):750-4. Epub 2007 Jan 8. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
(R)-2-(FORMYLOXY)-3-(PHOSPHONOOXY)PROPYL PENTANOATEexperimentalunknowntargetDetails