Phospholipase D

Details

Name
Phospholipase D
Kind
protein
Synonyms
  • 3.1.4.4
  • Choline phosphatase
Gene Name
Not Available
UniProtKB Entry
Q53728Swiss-Prot
Organism
Streptomyces antibioticus
NCBI Taxonomy ID
1890
Amino acid sequence
>lcl|BSEQ0017396|Phospholipase D
MTSDQRPARLPTHKGKLLAPHRLHRLIPVSVALTTVCAALPSSTAYAADTPPTPHLDAIE
RSLRDTSPGLEGSVWQRTDGNRLDAPDGDPAGWLLQTPGCWGDAGCKDRAGTRRLLDKMT
RNIADARHTVDISSLAPFPNGGFEDAVVDGLKAVVAAGHSPRVRILVGAAPIYHLNVVPS
RYRDELIGKLGAAAGKVTLNVASMTTSKTSLSWNHSKLLVVDGKTAITGGINGWKDDYLD
TAHPVSDVDMALSGPAAASAGKYLDTLWDWTCRNASDPAKVWLATSNGASCMPSMEQDEA
GSAPAEPTGDVPVIAVGGLGVGIKESDPSSGYHPDLPTAPDTKCTVGLHDNTNADRDYDT
VNPEENALRSLIASARSHVEISQQDLNATCPPLPRYDIRTYDTLAGKLAAGVKVRIVVSD
PANRGAVGSGGYSQIKSLDEISDTLRTRLVALTGDNEKASRALCGNLQLASFRSSDAAKW
ADGKPYALHHKLVSVDDSAFYIGSKNLYPAWLQDFGYIVESPAAAQQLKTELLDPEWKYS
QQAAATPAGCPARQAG
Number of residues
556
Molecular Weight
58931.455
Theoretical pI
6.39
GO Classification
Functions
N-acylphosphatidylethanolamine-specific phospholipase D activity / phospholipase D activity
Processes
lipid catabolic process
Components
extracellular region
General Function
A reversible phospholipase active on phosphatidylcholine (PC) and phosphatidylethanolamine. Lysophosphatidylcholine and egg sphingomyelin are hydrolyzed about 50 times and 100 times more slowly than PC, respectively. During the transphosphatidylation reaction straight-chain hydroxy compounds, such as triethyleneglycol and triethyleneglycol monomethyl ether, were phosphatidylated in good yield, as were monosaccharides. Disaccharides and sugar alcohol reacted slowly, while N-acetyl-D-galactosamine, D-galactosamine and D-galacturonic acid were not phosphatidylated.
Specific Function
cardiolipin synthase activity
Pfam Domain Function
Signal Regions
1-47
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0008157|1671 bp
ATGACCAGTGATCAGCGCCCGGCTCGCCTCCCCACGCACAAAGGCAAGCTCTTGGCTCCT
CACCGACTCCACCGCCTGATACCGGTGTCCGTCGCCCTGACGACCGTGTGCGCGGCACTG
CCGTCCTCGACGGCCTACGCCGCGGACACACCGCCCACCCCCCATCTGGACGCCATCGAG
CGGTCGCTGCGCGACACCTCCCCCGGCCTCGAAGGCTCGGTGTGGCAGCGCACGGACGGC
AACCGCCTGGACGCCCCGGACGGCGACCCCGCCGGCTGGCTGCTGCAGACCCCCGGCTGC
TGGGGCGACGCCGGCTGCAAGGACCGCGCCGGCACCCGGCGGCTGCTCGACAAGATGACC
CGCAACATCGCCGACGCCCGGCACACCGTGGACATCTCCTCGCTGGCCCCCTTCCCCAAC
GGCGGGTTCGAGGACGCGGTCGTCGACGGCCTCAAGGCGGTCGTCGCGGCGGGGCACTCC
CCGCGGGTGCGCATCCTGGTCGGCGCCGCCCCGATCTACCACCTCAACGTGGTGCCGTCC
CGCTACCGCGACGAGCTGATCGGCAAGCTCGGCGCGGCGGCCGGCAAGGTCACGCTCAAC
GTCGCCTCGATGACCACGTCCAAGACGTCGCTCTCCTGGAACCACTCCAAGCTCCTCGTG
GTCGACGGGAAGACGGCCATCACGGGCGGGATCAACGGCTGGAAGGACGACTACCTCGAC
ACCGCCCACCCGGTGTCGGACGTGGACATGGCGCTCAGCGGCCCGGCCGCCGCCTCGGCG
GGGAAGTACCTCGACACCCTCTGGGACTGGACCTGCCGCAACGCGTCCGACCCGGCCAAG
GTGTGGCTCGCCACGTCGAACGGCGCCTCCTGCATGCCGTCGATGGAGCAGGACGAGGCG
GGATCCGCCCCCGCCGAGCCCACCGGTGACGTCCCCGTCATCGCGGTCGGCGGCCTCGGC
GTGGGCATCAAGGAGTCCGACCCCTCCTCGGGATACCACCCGGACCTGCCGACGGCCCCG
GACACCAAGTGCACCGTGGGGCTGCACGACAACACCAACGCCGACCGCGACTACGACACG
GTCAACCCCGAGGAGAACGCGCTGCGTTCGCTCATCGCCAGCGCGCGCAGCCACGTCGAG
ATCTCCCAGCAGGACCTCAACGCCACCTGCCCGCCGTTGCCGCGCTACGACATCCGGACC
TACGACACCCTCGCGGGCAAGCTGGCCGCCGGGGTCAAGGTCCGCATCGTCGTCAGCGAT
CCCGCCAACCGCGGCGCCGTCGGCAGCGGGGGCTACTCCCAGATCAAGTCCCTGGACGAG
ATCAGCGACACCCTCCGCACGCGTCTCGTCGCCCTGACCGGCGACAACGAGAAGGCGTCG
CGGGCCCTGTGCGGCAACCTGCAGCTCGCCTCGTTCCGCAGCTCGGACGCCGCGAAGTGG
GCCGACGGCAAGCCGTACGCGCTGCACCACAAGCTGGTGTCGGTGGACGACTCGGCGTTC
TACATCGGCTCCAAGAACCTCTACCCGGCCTGGCTGCAGGACTTCGGCTACATCGTCGAG
AGCCCCGCCGCGGCCCAGCAGCTCAAGACCGAGCTGCTCGACCCGGAGTGGAAGTACTCC
CAGCAGGCGGCGGCCACCCCGGCCGGCTGCCCGGCTCGCCAGGCGGGCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ53728
UniProtKB Entry NamePLD_STRAT
GenBank Protein ID517155
GenBank Gene IDD16444
PDB ID(s)2ZE4, 2ZE9
General References
  1. Iwasaki Y, Nakano H, Yamane T: Phospholipase D from Streptomyces antibioticus: cloning, sequencing, expression, and relationship to other phospholipases. Appl Microbiol Biotechnol. 1994 Nov;42(2-3):290-9. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
(2R)-3-(phosphonooxy)propane-1,2-diyl diheptanoateexperimentalunknowntargetDetails