Phospholipase D
Details
- Name
- Phospholipase D
- Kind
- protein
- Synonyms
- 3.1.4.4
- Choline phosphatase
- Gene Name
- Not Available
- UniProtKB Entry
- Q53728Swiss-Prot
- Organism
- Streptomyces antibioticus
- NCBI Taxonomy ID
- 1890
- Amino acid sequence
>lcl|BSEQ0017396|Phospholipase D MTSDQRPARLPTHKGKLLAPHRLHRLIPVSVALTTVCAALPSSTAYAADTPPTPHLDAIE RSLRDTSPGLEGSVWQRTDGNRLDAPDGDPAGWLLQTPGCWGDAGCKDRAGTRRLLDKMT RNIADARHTVDISSLAPFPNGGFEDAVVDGLKAVVAAGHSPRVRILVGAAPIYHLNVVPS RYRDELIGKLGAAAGKVTLNVASMTTSKTSLSWNHSKLLVVDGKTAITGGINGWKDDYLD TAHPVSDVDMALSGPAAASAGKYLDTLWDWTCRNASDPAKVWLATSNGASCMPSMEQDEA GSAPAEPTGDVPVIAVGGLGVGIKESDPSSGYHPDLPTAPDTKCTVGLHDNTNADRDYDT VNPEENALRSLIASARSHVEISQQDLNATCPPLPRYDIRTYDTLAGKLAAGVKVRIVVSD PANRGAVGSGGYSQIKSLDEISDTLRTRLVALTGDNEKASRALCGNLQLASFRSSDAAKW ADGKPYALHHKLVSVDDSAFYIGSKNLYPAWLQDFGYIVESPAAAQQLKTELLDPEWKYS QQAAATPAGCPARQAG
- Number of residues
- 556
- Molecular Weight
- 58931.455
- Theoretical pI
- 6.39
- GO Classification
- FunctionsN-acylphosphatidylethanolamine-specific phospholipase D activity / phospholipase D activityProcesseslipid catabolic processComponentsextracellular region
- General Function
- A reversible phospholipase active on phosphatidylcholine (PC) and phosphatidylethanolamine. Lysophosphatidylcholine and egg sphingomyelin are hydrolyzed about 50 times and 100 times more slowly than PC, respectively. During the transphosphatidylation reaction straight-chain hydroxy compounds, such as triethyleneglycol and triethyleneglycol monomethyl ether, were phosphatidylated in good yield, as were monosaccharides. Disaccharides and sugar alcohol reacted slowly, while N-acetyl-D-galactosamine, D-galactosamine and D-galacturonic acid were not phosphatidylated.
- Specific Function
- cardiolipin synthase activity
- Pfam Domain Function
- PLDc_2 (PF13091)
- Signal Regions
- 1-47
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0008157|1671 bp ATGACCAGTGATCAGCGCCCGGCTCGCCTCCCCACGCACAAAGGCAAGCTCTTGGCTCCT CACCGACTCCACCGCCTGATACCGGTGTCCGTCGCCCTGACGACCGTGTGCGCGGCACTG CCGTCCTCGACGGCCTACGCCGCGGACACACCGCCCACCCCCCATCTGGACGCCATCGAG CGGTCGCTGCGCGACACCTCCCCCGGCCTCGAAGGCTCGGTGTGGCAGCGCACGGACGGC AACCGCCTGGACGCCCCGGACGGCGACCCCGCCGGCTGGCTGCTGCAGACCCCCGGCTGC TGGGGCGACGCCGGCTGCAAGGACCGCGCCGGCACCCGGCGGCTGCTCGACAAGATGACC CGCAACATCGCCGACGCCCGGCACACCGTGGACATCTCCTCGCTGGCCCCCTTCCCCAAC GGCGGGTTCGAGGACGCGGTCGTCGACGGCCTCAAGGCGGTCGTCGCGGCGGGGCACTCC CCGCGGGTGCGCATCCTGGTCGGCGCCGCCCCGATCTACCACCTCAACGTGGTGCCGTCC CGCTACCGCGACGAGCTGATCGGCAAGCTCGGCGCGGCGGCCGGCAAGGTCACGCTCAAC GTCGCCTCGATGACCACGTCCAAGACGTCGCTCTCCTGGAACCACTCCAAGCTCCTCGTG GTCGACGGGAAGACGGCCATCACGGGCGGGATCAACGGCTGGAAGGACGACTACCTCGAC ACCGCCCACCCGGTGTCGGACGTGGACATGGCGCTCAGCGGCCCGGCCGCCGCCTCGGCG GGGAAGTACCTCGACACCCTCTGGGACTGGACCTGCCGCAACGCGTCCGACCCGGCCAAG GTGTGGCTCGCCACGTCGAACGGCGCCTCCTGCATGCCGTCGATGGAGCAGGACGAGGCG GGATCCGCCCCCGCCGAGCCCACCGGTGACGTCCCCGTCATCGCGGTCGGCGGCCTCGGC GTGGGCATCAAGGAGTCCGACCCCTCCTCGGGATACCACCCGGACCTGCCGACGGCCCCG GACACCAAGTGCACCGTGGGGCTGCACGACAACACCAACGCCGACCGCGACTACGACACG GTCAACCCCGAGGAGAACGCGCTGCGTTCGCTCATCGCCAGCGCGCGCAGCCACGTCGAG ATCTCCCAGCAGGACCTCAACGCCACCTGCCCGCCGTTGCCGCGCTACGACATCCGGACC TACGACACCCTCGCGGGCAAGCTGGCCGCCGGGGTCAAGGTCCGCATCGTCGTCAGCGAT CCCGCCAACCGCGGCGCCGTCGGCAGCGGGGGCTACTCCCAGATCAAGTCCCTGGACGAG ATCAGCGACACCCTCCGCACGCGTCTCGTCGCCCTGACCGGCGACAACGAGAAGGCGTCG CGGGCCCTGTGCGGCAACCTGCAGCTCGCCTCGTTCCGCAGCTCGGACGCCGCGAAGTGG GCCGACGGCAAGCCGTACGCGCTGCACCACAAGCTGGTGTCGGTGGACGACTCGGCGTTC TACATCGGCTCCAAGAACCTCTACCCGGCCTGGCTGCAGGACTTCGGCTACATCGTCGAG AGCCCCGCCGCGGCCCAGCAGCTCAAGACCGAGCTGCTCGACCCGGAGTGGAAGTACTCC CAGCAGGCGGCGGCCACCCCGGCCGGCTGCCCGGCTCGCCAGGCGGGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q53728 UniProtKB Entry Name PLD_STRAT GenBank Protein ID 517155 GenBank Gene ID D16444 PDB ID(s) 2ZE4, 2ZE9 - General References
- Iwasaki Y, Nakano H, Yamane T: Phospholipase D from Streptomyces antibioticus: cloning, sequencing, expression, and relationship to other phospholipases. Appl Microbiol Biotechnol. 1994 Nov;42(2-3):290-9. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details (2R)-3-(phosphonooxy)propane-1,2-diyl diheptanoate experimental unknown target Details