Adenylosuccinate synthetase
Details
- Name
- Adenylosuccinate synthetase
- Kind
- protein
- Synonyms
- 6.3.4.4
- AMPSase
- IMP--aspartate ligase
- Gene Name
- purA
- UniProtKB Entry
- Q8ZIV7Swiss-Prot
- Organism
- Yersinia pestis
- NCBI Taxonomy ID
- 632
- Amino acid sequence
>lcl|BSEQ0008190|Adenylosuccinate synthetase MGKNVVVLGTQWGDEGKGKVVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGI LRENVISIIGNGVVLAPDALMKEMTELEARGVPVRERLLLSEACPLILPYHVALDNAREK ARGAKAIGTTGRGIGPAYEDKVARRGLRVSDLFNKETFAIKLKEIVEYHNFQLVHYYKEA AVDYQKVLDDVLAIADILTAMVVDVSELLDNARKQGELIMFEGAQGTLLDIDHGTYPYVT SSNTTAGGVATGSGLGPRYVDYVLGIVKAYSTRVGAGPFPTELNDETGEFLRKQGNEYGA TTGRSRRTGWLDIVAVRRAVQINSLSGFCMTKLDVLDGLKEVKLCVGYRMPDGREVDTTP LAAEGWEGIEPIYETMPGWSETTFGVKEHSKLPQAALNYIQRVEELTGVPIDIISTGPDR DETMILRDPFDA
- Number of residues
- 432
- Molecular Weight
- 47277.655
- Theoretical pI
- 5.24
- GO Classification
- Functionsadenylosuccinate synthase activity / GTP binding / magnesium ion bindingProcesses'de novo' AMP biosynthetic processComponentscytoplasm
- General Function
- Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
- Specific Function
- adenylosuccinate synthase activity
- Pfam Domain Function
- Adenylsucc_synt (PF00709)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0013005|Adenylosuccinate synthetase (purA) ATGGGTAAGAACGTCGTCGTACTGGGCACCCAATGGGGTGACGAAGGTAAGGGCAAGGTC GTTGACCTGCTGACTGAACGGGCTAAATATGTTGTGCGCTATCAAGGTGGCCATAACGCG GGCCATACTTTGGTTATCAACGGTGAGAAAACCGTTCTTCATTTAATTCCCTCAGGTATT CTACGTGAAAACGTAATCAGCATCATCGGCAACGGTGTTGTACTGGCTCCTGACGCGTTG ATGAAAGAGATGACAGAGCTTGAAGCGCGCGGTGTGCCTGTTCGTGAGCGACTGTTACTC TCCGAAGCATGCCCATTGATCCTGCCTTATCATGTGGCTCTGGATAATGCGCGTGAAAAA GCACGTGGTGCAAAAGCTATCGGTACTACCGGTCGTGGTATTGGCCCTGCCTATGAAGAT AAAGTTGCTCGCCGCGGCCTACGCGTCAGTGACTTGTTCAATAAAGAAACCTTCGCTATC AAGCTGAAAGAAATTGTGGAATACCACAACTTCCAGTTGGTGCATTACTACAAAGAAGCG GCGGTTGACTACCAAAAAGTGCTGGATGATGTATTGGCTATCGCCGATATTCTGACGGCC ATGGTAGTTGATGTTTCTGAATTGTTGGACAATGCCCGTAAGCAAGGCGAGTTGATCATG TTCGAAGGCGCACAAGGCACCTTGCTGGACATCGACCACGGTACTTATCCGTATGTCACC TCATCTAACACCACCGCGGGTGGCGTAGCGACAGGCTCTGGCCTGGGTCCACGTTATGTT GATTACGTGCTGGGTATCGTAAAAGCCTATTCTACCCGTGTAGGTGCAGGTCCATTCCCT ACCGAACTGAACGATGAAACTGGTGAGTTCCTGCGCAAGCAAGGTAACGAATATGGCGCG ACTACCGGCCGTAGCCGTCGTACTGGCTGGTTGGATATCGTAGCCGTTCGCCGTGCAGTG CAGATCAACTCCCTGTCTGGTTTCTGCATGACCAAACTGGATGTGCTGGATGGTCTGAAA GAAGTGAAGCTCTGTGTTGGCTACCGTATGCCTGATGGCCGCGAAGTTGATACAACGCCA CTGGCTGCAGAAGGCTGGGAAGGCATCGAGCCAATCTACGAAACCATGCCAGGTTGGTCA GAAACCACCTTTGGTGTGAAGGAACACAGTAAGTTGCCACAGGCAGCCCTGAACTACATT CAACGTGTAGAAGAGCTGACAGGTGTGCCGATTGATATCATCTCTACCGGCCCTGATCGT GACGAAACCATGATCCTGCGTGATCCATTTGATGCATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8ZIV7 UniProtKB Entry Name PURA_YERPE GenBank Protein ID 115345833 GenBank Gene ID AL590842 PDB ID(s) 3HID KEGG ID ype:YPO0378 NCBI Gene ID 1173224 - General References
- Parkhill J, Wren BW, Thomson NR, Titball RW, Holden MT, Prentice MB, Sebaihia M, James KD, Churcher C, Mungall KL, Baker S, Basham D, Bentley SD, Brooks K, Cerdeno-Tarraga AM, Chillingworth T, Cronin A, Davies RM, Davis P, Dougan G, Feltwell T, Hamlin N, Holroyd S, Jagels K, Karlyshev AV, Leather S, Moule S, Oyston PC, Quail M, Rutherford K, Simmonds M, Skelton J, Stevens K, Whitehead S, Barrell BG: Genome sequence of Yersinia pestis, the causative agent of plague. Nature. 2001 Oct 4;413(6855):523-7. [Article]
- Deng W, Burland V, Plunkett G 3rd, Boutin A, Mayhew GF, Liss P, Perna NT, Rose DJ, Mau B, Zhou S, Schwartz DC, Fetherston JD, Lindler LE, Brubaker RR, Plano GV, Straley SC, McDonough KA, Nilles ML, Matson JS, Blattner FR, Perry RD: Genome sequence of Yersinia pestis KIM. J Bacteriol. 2002 Aug;184(16):4601-11. [Article]
- Song Y, Tong Z, Wang J, Wang L, Guo Z, Han Y, Zhang J, Pei D, Zhou D, Qin H, Pang X, Han Y, Zhai J, Li M, Cui B, Qi Z, Jin L, Dai R, Chen F, Li S, Ye C, Du Z, Lin W, Wang J, Yu J, Yang H, Wang J, Huang P, Yang R: Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans. DNA Res. 2004 Jun 30;11(3):179-97. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Pentaglyme experimental unknown target Details