Penicillin-binding protein 1B

Details

Name
Penicillin-binding protein 1B
Kind
protein
Synonyms
  • Penicillin-binding protein 1b
Gene Name
pbp1b
UniProtKB Entry
O70038TrEMBL
Organism
Streptococcus pneumoniae
NCBI Taxonomy ID
1313
Amino acid sequence
>lcl|BSEQ0022104|Penicillin-binding protein 1B
MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKSAIFPAILLSIKALFNL
LFVLGFLGGMLGAGIALGYGVALFDKVRVPQTEELVNQVKDISSISEITYSDGTVIASIE
SDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAVIRATLGKFVGLGSSSGGSTL
TQQLIKQQVVGDAPTLARKAAEIVDALALERAMNKDEILTTYLNVAPFGRNNKGQNIAGA
RQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPYENTGELKSDEDLEIGLRRAKAVLY
SMYRTGALSKDEYSQYKDYDLKQDFLPSGTVTGISRDYLYFTTLAEAQERMYDYLAQRDN
VSAKELKNEATQKFYRDLAAKEIENGGYKITTTIDQKIHSAMQSAVADYGYLLDDGTGRV
EVGNVLMDNQTGAILGFVGGRNYQENQNNHAFDTKRSPASTTKPLLAYGIAIDQGLMGSE
TILSNYPTNFANGNPIMYANSKGTGMMTLGEALNYSWNIPAYWTYRMLRENGVDVKGYME
KMGYEIPEYGIESLPMGGGIEVTVAQHTNGYQTLANNGVYHQKHVISKIEAADGRVVYEY
QDKPVQVYSKATATIMQGLLREVLSSRVTTTFKSNLTSLNPTLANADWIGKTGTTNQDEN
MWLMLSTPRLTLGGWIGHDDNHSLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALD
PSVVKSEVLKSTGQKPGKVSVEGKEVEVTGSTVTSYWANKSGAPATSYRFAIGGSDADYQ
NAWSSIVGSLPTPSSSSSSSSSSSDSSNSSTTRPSSSRARR
Number of residues
821
Molecular Weight
89479.92
Theoretical pI
8.82
GO Classification
Functions
penicillin binding
Components
integral component of membrane
General Function
Not Available
Specific Function
penicillin binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
60-84
Cellular Location
Not Available
Gene sequence
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDO70038
UniProtKB Entry NameO70038_STREE
GenBank Protein ID6165962
GenBank Gene IDAF101781
PDB ID(s)2BG1, 2FFF, 2JCH, 2JE5
General References
  1. Hakenbeck R, Konig A, Kern I, van der Linden M, Keck W, Billot-Klein D, Legrand R, Schoot B, Gutmann L: Acquisition of five high-Mr penicillin-binding protein variants during transfer of high-level beta-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae. J Bacteriol. 1998 Apr;180(7):1831-40. [Article]
  2. Hoskins J, Matsushima P, Mullen DL, Tang J, Zhao G, Meier TI, Nicas TI, Jaskunas SR: Gene disruption studies of penicillin-binding proteins 1a, 1b, and 2a in Streptococcus pneumoniae. J Bacteriol. 1999 Oct;181(20):6552-5. [Article]
  3. Sanbongi Y, Ida T, Ishikawa M, Osaki Y, Kataoka H, Suzuki T, Kondo K, Ohsawa F, Yonezawa M: Complete sequences of six penicillin-binding protein genes from 40 Streptococcus pneumoniae clinical isolates collected in Japan. Antimicrob Agents Chemother. 2004 Jun;48(6):2244-50. [Article]
  4. Macheboeuf P, Di Guilmi AM, Job V, Vernet T, Dideberg O, Dessen A: Active site restructuring regulates ligand recognition in class A penicillin-binding proteins. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):577-82. Epub 2005 Jan 6. [Article]
  5. Lovering AL, De Castro L, Lim D, Strynadka NC: Structural analysis of an "open" form of PBP1B from Streptococcus pneumoniae. Protein Sci. 2006 Jul;15(7):1701-9. Epub 2006 Jun 2. [Article]
  6. Macheboeuf P, Fischer DS, Brown T Jr, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ: Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. Nat Chem Biol. 2007 Sep;3(9):565-9. Epub 2007 Aug 5. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
(2E)-2-({(2S)-2-CARBOXY-2-[(PHENOXYACETYL)AMINO]ETHOXY}IMINO)PENTANEDIOIC ACIDexperimentalunknowntargetDetails