H2HPP isomerase

BE0004317ProteinBacillus subtilis (strain 168)bacB

Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. It is acted on by 1 drug in DrugBank.

Gene name
bacB
UniProtKB entry
P39639Swiss-Prot
Residues / weight
235 residues · 26,839 Da
Also known as
3-((4R)-4-hydroxycyclohexa-1,5-dien-1-yl)-2-oxopropanoate isomerase · 5.3.3.19 · Bacilysin biosynthesis protein BacB · Bi-cupin protein · ywfC

Resolves to

Protein
UniProtP39639UniProt nameBACB_BACSU
Gene
NCBI Gene937084GenBank413924
Pharmacology
KEGGbsu:BSU37730
Structure
PDB3H7JPDB3H7YPDB3H9A
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on H2HPP isomerase, and which indications are they being tested in?

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