Glycylpeptide N-tetradecanoyltransferase 1

BE0004329ProteinHumansNMT1

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:25255805, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952). It is acted on by 2 drugs in DrugBank.

Gene name
NMT1
UniProtKB entry
P30419Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
496 residues · 56,806 Da
Also known as
2.3.1.97 · HsNMT1 · Myristoyl-CoA:protein N-myristoyltransferase 1 · NMT · NMT 1

Resolves to

Protein
UniProtP30419UniProt nameNMT1_HUMAN
Gene
HGNCHGNC:7857NCBI Gene4836GenBank3005063GeneCardsNMT1
Pharmacology
IUPHAR/GtoPdb3308KEGGhsa:4836
Structure
PDB1RXTPDB3IU1PDB3IU2
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Glycylpeptide N-tetradecanoyltransferase 1, and which indications are they being tested in?

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