Virulence sensor histidine kinase PhoQ

BE0004331ProteinSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)phoQ

Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. It is acted on by 1 drug in DrugBank.

Gene name
phoQ
UniProtKB entry
P0DM80Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
487 residues · 55,466 Da
Also known as
2.7.13.3 · phoZ · Sensor histidine protein kinase/phosphatase PhoQ

Resolves to

Protein
UniProtP0DM80UniProt namePHOQ_SALTY
Gene
NCBI Gene1252748
Pharmacology
KEGGstm:STM1230
Structure
PDB1YAXPDB3CGYPDB3CGZ
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Virulence sensor histidine kinase PhoQ, and which indications are they being tested in?

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