ActII protein
Details
- Name
- ActII protein
- Kind
- protein
- Synonyms
- SubName: ActII protein
- Gene Name
- actII
- UniProtKB Entry
- Q53901TrEMBL
- Organism
- Streptomyces coelicolor
- NCBI Taxonomy ID
- 1902
- Amino acid sequence
>lcl|BSEQ0013026|ActII protein MSRSEEGRPMPEEIPVPPWRRPKKAPPRMPLTQDRIVVTALGILDAEGLDALSMRRLAQE LKTGHASLYAHVGNRDELLDLVFDIVLTEVEVPEPEPGRWAEQVKEMCRSLRRMFLAHRD LARIAIDRVPLGPNGMVGMERTMNLLRSGGLHDELAAYGGDLLSTFVTAEALEQSSRNPG TEQGREQAGVFADQLHGYLKSLPATSFPNLVHLAGPITSLDSDRRFELGLEIIIAGLLAG AGEAADDQVRTAGSPPAES
- Number of residues
- 259
- Molecular Weight
- 28267.92
- Theoretical pI
- 4.94
- GO Classification
- FunctionsDNA bindingProcessesnegative regulation of transcription, DNA-templated / response to antibiotic / transcription, DNA-templated
- General Function
- TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
- Specific Function
- DNA-binding transcription factor activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0008239|1737 bp ATGAGTTCCGTTGAAGCCGACGAGCCGGACAGGGCCACGGCCCCGCCGTCGGCGTTACTG CCCGAGGACGGCCCCGGACCGGACGGAACCGCGGCCGGACCCCCGCCCTACGCGCGCCGT TGGGCCGCGCTGGGAGTCATCCTCGGCGCCGAGATCATGGACCTGCTCGACGGCACGGTC ATGAACGTGGCCGCGCCCGCCGTCCGCGCGGACCTGGGCGGCAGCCTCAGCGTCATCCAG TGGATCACCGTCGGGTACACGCTCGCGTTCGCCGTCCTGCTCGTGGTGGGCGGCCGGCTG GGCGACATCTACGGCCGCAAGCGCATGTTCGTCGTCGGCGCCGTCGGCTTCACCGCGGCC TCCGTGCTGTGCTCGGTGGCGGCCGGTCCCGAGATGCTCACCGCGGCACGCTTCCTTCAG GGCGGGCTCGGCGCGCTGATGATTCCGCAAGGGCTCGGTCTCATCAAGCAAATGTTCCCG CCCAAGGAGACGGCGGCGGCGTTCGGCGCGTTCGGACCCGCCATCGGGCTGGGCGCCGTG CTCGGCCCGATCGTCGCCGGGTTCCTGGTCGACGCCGACCTGTTCGGCACGGGCTGGCGG TCCGTCTTCCTGATCAATCTGCCGATCGGCGTGGCCGTGATCGTCGGCGCGGTCCTGCTG CTGCCCGAGGGCAAGGCGCCCGTGCGGCCGAAGTTCGACGTCGTCGGCATGGCGCTGGTG ACGTCCGGGCTCACCCTGCTCATCTTCCCGCTCGTCCAGGGGCGCGAACGCGGCTGGCCC GCCTGGGCGTTCGTGCTGATGCTGGCCGGAGCGGCCGTGCTCGTCGGCTTCGTCGCCCAC GAACTGCGGCAGGAGAGGCGCGGCGGCGCCACGCTCATCGAGCTCAGCCTGCTGCGCAGG TCCCGCTACGCCGCGGGACTGGCGGTGGCACTGGTGTTCTTCACCGGCGTCTCCGGAATG TCGCTGCTGCTCGCCCTGCACCTGCAGATCGGCCTGGGCTTCAGCCCCACCAGGGCCGCG CTGACCATGACGCCCTGGTCGGTGTTCCTCGTCGTCGGCGCGATCCTGACCGGGGCGGTG CTGGGATCGAAGTTCGGCCGCAAGGCCCTGCACGGCGGGCTCGTGGTGCTGGCGCTGGGC GTGCTGATCATGCTGTTGACGATCGGCGACCAGGCCGGCGGGCTGACCAGCTGGGAGCTC GTCCCCGGTATCGCCGTTGCCGGGCTCGGCATGGGCATCATGATCGGACTGCTCTTCGAC ATCGCCCTGGCCGACGTCGACAAGCAGGAGGCCGGTACCGCCTCCGGCGTCCTCACCGCG GTCCAGCAGCTCGGCTTCACCGTGGGCGTCGCGGTGCTCGGGACCCTGTTCTTCGGGCTG CTCGGCTCACAGGCCACGGCGAGCGTCGACGACGGCGCGAGCCGGGCCCGCACCGAACTC GCCGCCGCCGGGGCGAGCACGACCGAGCAGGACCGGCTCCTGGCCGACCTGCGGGTGTGC CTGCGGGAATCGGCGAGTCAGCAGGACTCCGAACGGACGCCGGACAGCTGCCGAAACCTC CAGCAGGCCCGGCCGGCGGTGGCCGAGGCCACGGCGCGGGCCTGGCGGACGGCCCACACC GAGAACTTCAGCACCGCGATGGTCCGCACGCTCTGGGTGGTGATCGCACTGCTGGCGGTC TCCTTCGCGCTGGCCTTCCGGCTGCCGCCCAAGCCGCGTGAGGAAGAGGGCTTCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q53901 UniProtKB Entry Name Q53901_STRCH GenBank Protein ID 455360 GenBank Gene ID M64683 PDB ID(s) 2OPT, 3B6A, 3B6C - General References
- Fernandez-Moreno MA, Caballero JL, Hopwood DA, Malpartida F: The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces. Cell. 1991 Aug 23;66(4):769-80. [Article]
- Willems AR, Tahlan K, Taguchi T, Zhang K, Lee ZZ, Ichinose K, Junop MS, Nodwell JR: Crystal structures of the Streptomyces coelicolor TetR-like protein ActR alone and in complex with actinorhodin or the actinorhodin biosynthetic precursor (S)-DNPA. J Mol Biol. 2008 Mar 7;376(5):1377-87. doi: 10.1016/j.jmb.2007.12.061. Epub 2008 Jan 4. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details [(3S)-9-hydroxy-1-methyl-10-oxo-4,10-dihydro-3H-benzo[g]isochromen-3-yl]acetic acid experimental unknown target Details