Iron-dependent extradiol dioxygenase

BE0004337ProteinMycobacterium tuberculosishsaC

Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA). It is acted on by 1 drug in DrugBank.

Gene name
hsaC
UniProtKB entry
P9WNW7Swiss-Prot
Residues / weight
300 residues · 33,582 Da
Also known as
1.13.11.25 · bphC

Resolves to

Protein
UniProtP9WNW7UniProt nameHSAC_MYCTU
Gene
NCBI Gene887886
Pharmacology
KEGGmtu:Rv3568c
Structure
PDB2ZI8PDB2ZYQ
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Iron-dependent extradiol dioxygenase, and which indications are they being tested in?

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