Iron-dependent extradiol dioxygenase
Details
- Name
- Iron-dependent extradiol dioxygenase
- Kind
- protein
- Synonyms
- 1.13.11.25
- bphC
- Gene Name
- hsaC
- UniProtKB Entry
- P9WNW7Swiss-Prot
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- NCBI Taxonomy ID
- 83332
- Amino acid sequence
>lcl|BSEQ0051272|Iron-dependent extradiol dioxygenase MSIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYLRMDDFPARLVVVPGEHDR LLEAGWECANAEGLQEIRNRLDLEGTPYKEATAAELADRRVDEMIRFADPSGNCLEVFHG TALEHRRVVSPYGHRFVTGEQGMGHVVLSTRDDAEALHFYRDVLGFRLRDSMRLPPQMVG RPADGPPAWLRFFGCNPRHHSLAFLPMPTSSGIVHLMVEVEQADDVGLCLDRALRRKVPM SATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVDDRDWIARESTAVSLWGHDFTVGARG
- Number of residues
- 300
- Molecular Weight
- 33581.985
- Theoretical pI
- Not Available
- GO Classification
- Functions3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity / ferrous iron binding / iron ion bindingProcessesaromatic compound catabolic process / cholesterol catabolic process / pathogenesis / response to cholesterol
- General Function
- Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA).
- Specific Function
- 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity
- Pfam Domain Function
- Glyoxalase (PF00903)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051273|Iron-dependent extradiol dioxygenase (hsaC) ATGAGCATCCGGTCGCTGGGCTATCTGCGCATCGAGGCCACTGACATGGCTGCCTGGCGG GAGTATGGACTGAAGGTCCTGGGCATGGTCGAGGGCAAAGGGGCCCCAGAAGGGGCCCTG TATCTGCGGATGGATGACTTTCCGGCCCGGCTGGTGGTCGTGCCCGGTGAGCACGACAGG CTGTTGGAGGCCGGTTGGGAATGCGCGAATGCCGAAGGCCTGCAGGAAATCCGGAACCGC CTGGATTTGGAGGGCACGCCGTACAAAGAGGCCACCGCCGCCGAGCTGGCCGATCGCCGG GTGGACGAGATGATCCGGTTTGCCGACCCTTCCGGCAATTGCCTGGAGGTCTTCCACGGT ACCGCGCTGGAACACCGCCGAGTGGTCAGCCCGTATGGGCACAGGTTCGTCACCGGTGAG CAGGGTATGGGCCATGTGGTGCTGTCCACCCGCGACGATGCTGAGGCGTTGCATTTCTAC CGAGACGTGCTCGGCTTTCGGCTGCGTGACTCGATGCGGCTACCGCCACAGATGGTAGGG CGGCCCGCCGACGGGCCGCCAGCCTGGCTGCGTTTCTTCGGCTGTAACCCGCGTCACCAC TCGTTGGCCTTCCTGCCGATGCCGACGTCCAGCGGCATCGTGCACCTGATGGTCGAGGTC GAGCAGGCCGACGACGTGGGCCTGTGCCTGGACCGGGCGTTGCGGCGCAAGGTGCCGATG TCGGCCACCCTGGGCCGGCATGTCAACGACCTGATGCTGTCGTTCTACATGAAGACGCCC GGTGGCTTCGACATCGAATTCGGTTGTGAGGGCAGGCAAGTCGACGATCGGGACTGGATC GCCCGGGAGAGTACTGCGGTCAGCCTATGGGGTCACGATTTCACCGTAGGCGCTCGCGGC TAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WNW7 UniProtKB Entry Name HSAC_MYCTU PDB ID(s) 2ZI8, 2ZYQ KEGG ID mtu:Rv3568c NCBI Gene ID 887886 - General References
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Kendall SL, Withers M, Soffair CN, Moreland NJ, Gurcha S, Sidders B, Frita R, Ten Bokum A, Besra GS, Lott JS, Stoker NG: A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol Microbiol. 2007 Aug;65(3):684-99. [Article]
- Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD: A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1947-52. Epub 2007 Jan 30. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
- Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR Jr, Strynadka N, Eltis LD: Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis. PLoS Pathog. 2009 Mar;5(3):e1000344. doi: 10.1371/journal.ppat.1000344. Epub 2009 Mar 20. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 3,4-dihydroxy-9,10-secoandrosta-1(10),2,4-triene-9,17-dione experimental unknown target Details