Immunoglobulin kappa variable 2D-28
Details
- Name
- Immunoglobulin kappa variable 2D-28
- Kind
- protein
- Synonyms
- Ig kappa chain V-II region FR
- Ig kappa chain V-II region GM607
- Ig kappa chain V-II region MIL
- Ig kappa chain V-II region TEW
- Gene Name
- IGKV2D-28
- UniProtKB Entry
- P01615Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0049972|Immunoglobulin kappa variable 2D-28 MRLPAQLLGLLMLWVSGSSGDIVMTQSPLSLPVTPGEPASISCRSSQSLLHSNGYNYLDW YLQKPGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQALQTP
- Number of residues
- 120
- Molecular Weight
- 12956.625
- Theoretical pI
- Not Available
- GO Classification
- Functionsantigen bindingProcessesimmune responseComponentsblood microparticle / extracellular exosome / extracellular region / plasma membrane
- General Function
- V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)
- Specific Function
- antigen binding
- Pfam Domain Function
- V-set (PF07686)
- Signal Regions
- 1-19
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
- Not Available
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P01615 UniProtKB Entry Name KVD28_HUMAN GeneCard ID IGKV2D-28 HGNC ID HGNC:5799 - General References
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- Putnam FW, Whitley EJ Jr, Paul C, Davidson JN: Amino acid sequence of a kappa Bence Jones protein from a case of primary amyloidosis. Biochemistry. 1973 Sep 11;12(19):3763-80. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID experimental unknown target Details