Afadin

BE0004342ProteinHumansAFDN

Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). It is acted on by 1 drug in DrugBank.

Gene name
AFDN
UniProtKB entry
P55196Swiss-Prot
Cellular location
Cell junction, adherens junction
Residues / weight
1,824 residues · 206,802 Da
Also known as
AF6 · Afadin adherens junction formation factor · ALL1-fused gene from chromosome 6 protein · MLLT4 · Protein AF-6

Resolves to

Protein
UniProtP55196UniProt nameAFAD_HUMAN
Gene
HGNCHGNC:7137NCBI Gene4301GenBank430994GeneCardsAFDN
Pharmacology
KEGGhsa:4301
Structure
PDB1T2MPDB1XZ9PDB2AIN
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Afadin, and which indications are they being tested in?

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