Actinorhodin polyketide synthase acyl carrier protein

Details

Name
Actinorhodin polyketide synthase acyl carrier protein
Kind
protein
Synonyms
  • ACP
  • actI ORF3
Gene Name
Not Available
UniProtKB Entry
Q02054Swiss-Prot
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
NCBI Taxonomy ID
100226
Amino acid sequence
>lcl|BSEQ0013028|Actinorhodin polyketide synthase acyl carrier protein
MATLLTTDDLRRALVECAGETDGTDLSGDFLDLRFEDIGYDSLALMETAARLESRYGVSI
PDDVAGRVDTPRELLDLINGALAEAA
Number of residues
86
Molecular Weight
9248.115
Theoretical pI
3.78
GO Classification
Processes
antibiotic biosynthetic process
General Function
Acyl carrier protein.
Specific Function
acyl binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0013029|Actinorhodin polyketide synthase acyl carrier protein
ATGGCAACCCTGCTGACCACCGACGATCTGCGCCGCGCCCTCGTGGAGTGCGCCGGTGAG
ACGGACGGGACGGACCTGTCCGGCGACTTCCTCGACCTCCGCTTCGAGGACATCGGGTAC
GACTCGCTCGCCCTGATGGAGACCGCGGCGCGACTCGAGAGCCGGTACGGCGTGTCCATA
CCCGACGACGTCGCCGGCCGCGTCGACACGCCGCGAGAGCTGCTCGACCTGATCAACGGC
GCACTGGCCGAGGCGGCATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ02054
UniProtKB Entry NameACPX_STRCO
GenBank Protein ID581608
GenBank Gene IDX63449
PDB ID(s)1AF8, 1NNZ, 2AF8, 2K0X, 2K0Y, 2KG6, 2KG8, 2KG9, 2KGA, 2KGC, 2KGD, 2KGE, 2MVU, 2MVV
KEGG IDsco:SCO5089
NCBI Gene ID1100530
General References
  1. Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F: Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin. J Biol Chem. 1992 Sep 25;267(27):19278-90. [Article]
  2. Bentley SD, Chater KF, Cerdeno-Tarraga AM, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper D, Bateman A, Brown S, Chandra G, Chen CW, Collins M, Cronin A, Fraser A, Goble A, Hidalgo J, Hornsby T, Howarth S, Huang CH, Kieser T, Larke L, Murphy L, Oliver K, O'Neil S, Rabbinowitsch E, Rajandream MA, Rutherford K, Rutter S, Seeger K, Saunders D, Sharp S, Squares R, Squares S, Taylor K, Warren T, Wietzorrek A, Woodward J, Barrell BG, Parkhill J, Hopwood DA: Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature. 2002 May 9;417(6885):141-7. [Article]
  3. Crump MP, Crosby J, Dempsey CE, Parkinson JA, Murray M, Hopwood DA, Simpson TJ: Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2). Biochemistry. 1997 May 20;36(20):6000-8. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] hexanethioateexperimentalunknowntargetDetails
S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioateexperimentalunknowntargetDetails