Actinorhodin polyketide synthase acyl carrier protein
Details
- Name
- Actinorhodin polyketide synthase acyl carrier protein
- Kind
- protein
- Synonyms
- ACP
- actI ORF3
- Gene Name
- Not Available
- UniProtKB Entry
- Q02054Swiss-Prot
- Organism
- Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
- NCBI Taxonomy ID
- 100226
- Amino acid sequence
>lcl|BSEQ0013028|Actinorhodin polyketide synthase acyl carrier protein MATLLTTDDLRRALVECAGETDGTDLSGDFLDLRFEDIGYDSLALMETAARLESRYGVSI PDDVAGRVDTPRELLDLINGALAEAA
- Number of residues
- 86
- Molecular Weight
- 9248.115
- Theoretical pI
- 3.78
- GO Classification
- Processesantibiotic biosynthetic process
- General Function
- Acyl carrier protein.
- Specific Function
- acyl binding
- Pfam Domain Function
- PP-binding (PF00550)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0013029|Actinorhodin polyketide synthase acyl carrier protein ATGGCAACCCTGCTGACCACCGACGATCTGCGCCGCGCCCTCGTGGAGTGCGCCGGTGAG ACGGACGGGACGGACCTGTCCGGCGACTTCCTCGACCTCCGCTTCGAGGACATCGGGTAC GACTCGCTCGCCCTGATGGAGACCGCGGCGCGACTCGAGAGCCGGTACGGCGTGTCCATA CCCGACGACGTCGCCGGCCGCGTCGACACGCCGCGAGAGCTGCTCGACCTGATCAACGGC GCACTGGCCGAGGCGGCATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q02054 UniProtKB Entry Name ACPX_STRCO GenBank Protein ID 581608 GenBank Gene ID X63449 PDB ID(s) 1AF8, 1NNZ, 2AF8, 2K0X, 2K0Y, 2KG6, 2KG8, 2KG9, 2KGA, 2KGC, 2KGD, 2KGE, 2MVU, 2MVV KEGG ID sco:SCO5089 NCBI Gene ID 1100530 - General References
- Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F: Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin. J Biol Chem. 1992 Sep 25;267(27):19278-90. [Article]
- Bentley SD, Chater KF, Cerdeno-Tarraga AM, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper D, Bateman A, Brown S, Chandra G, Chen CW, Collins M, Cronin A, Fraser A, Goble A, Hidalgo J, Hornsby T, Howarth S, Huang CH, Kieser T, Larke L, Murphy L, Oliver K, O'Neil S, Rabbinowitsch E, Rajandream MA, Rutherford K, Rutter S, Seeger K, Saunders D, Sharp S, Squares R, Squares S, Taylor K, Warren T, Wietzorrek A, Woodward J, Barrell BG, Parkhill J, Hopwood DA: Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature. 2002 May 9;417(6885):141-7. [Article]
- Crump MP, Crosby J, Dempsey CE, Parkinson JA, Murray M, Hopwood DA, Simpson TJ: Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2). Biochemistry. 1997 May 20;36(20):6000-8. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] hexanethioate experimental unknown target Details S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate experimental unknown target Details