Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI

BE0004347ProteinStaphylococcus aureus (strain MRSA252)fabI

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). It is acted on by 5 drugs in DrugBank.

Gene name
fabI
UniProtKB entry
Q6GI75Swiss-Prot
Residues / weight
256 residues · 27,992 Da
Also known as
1.3.1.39 · ENR · NADPH-dependent enoyl-ACP reductase

Resolves to

Protein
UniProtQ6GI75UniProt nameFABI_STAAR
Gene
NCBI Gene23196791GenBank49240383
Pharmacology
KEGGsar:SAR0978
Structure
PDB3GNSPDB3GNTPDB3GR6
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI, how selective are they, and which programs against it are still in active trials?

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