[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

BE0004348ProteinHumansPDK2

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. It is acted on by 4 drugs in DrugBank.

Gene name
PDK2
UniProtKB entry
Q15119Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
407 residues · 46,153 Da
Also known as
2.7.11.2 · PDH kinase 2 · PDHK2 · PDKII · Pyruvate dehydrogenase kinase isoform 2

Resolves to

Protein
UniProtQ15119UniProt namePDK2_HUMAN
Gene
HGNCHGNC:8810NCBI Gene5164GenBank1088283GeneCardsPDK2
Pharmacology
IUPHAR/GtoPdb2142KEGGhsa:5164
Structure
PDB2BTZPDB2BU2PDB2BU5
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, how selective are they, and which programs against it are still in active trials?

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