3-oxoacyl-[acyl-carrier-protein] synthase 1

BE0004351ProteinMycobacterium tuberculosiskasA

Part of the mycobacterial fatty acid elongation system FAS-II, which is involved in mycolic acid biosynthesis. It is acted on by 1 drug in DrugBank.

Gene name
kasA
UniProtKB entry
P9WQD9Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
416 residues · 43,316 Da
Also known as
2.3.1.293 · 2.3.1.41 · Beta-ketoacyl-ACP synthase 1 · Beta-ketoacyl-acyl carrier protein synthase KasA · KAS 1

Resolves to

Protein
UniProtP9WQD9UniProt nameKASA_MYCTU
Gene
NCBI Gene887269
Pharmacology
KEGGmtu:Rv2245
Structure
PDB2WGDPDB2WGEPDB2WGF
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 3-oxoacyl-[acyl-carrier-protein] synthase 1, and which indications are they being tested in?

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