Tyrosine--tRNA ligase

BE0004369ProteinAPMVYARS

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). It is acted on by 1 drug in DrugBank.

Gene name
YARS
UniProtKB entry
Q5UPJ7Swiss-Prot
Residues / weight
346 residues · 39,722 Da
Also known as
6.1.1.1 · Tyrosyl-tRNA synthetase · TyrRS

Resolves to

Protein
UniProtQ5UPJ7UniProt nameSYY_MIMIV
Gene
NCBI Gene9924723GenBank55416626
Pharmacology
KEGGvg:9924723
Structure
PDB2J5B
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Tyrosine--tRNA ligase, and which indications are they being tested in?

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