Serine hydrolase BPHL

BE0004370ProteinHumansBPHL

Specific alpha-amino acid ester serine hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol (PubMed:12732646, PubMed:15832508, PubMed:18256025, PubMed:25333274,... It is acted on by 1 drug in DrugBank.

Gene name
BPHL
UniProtKB entry
Q86WA6Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
291 residues · 32,542 Da
Also known as
3.1.-.- · Biphenyl hydrolase-like protein · Biphenyl hydrolase-related protein · Bph-rp · Breast epithelial mucin-associated antigen

Resolves to

Protein
UniProtQ86WA6UniProt nameBPHL_HUMAN
Gene
HGNCHGNC:1094NCBI Gene670GenBank984663GeneCardsBPHL
Pharmacology
KEGGhsa:670
Structure
PDB2OCGPDB2OCIPDB2OCK
Drugs

What you can answer from here — as of June 26, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Serine hydrolase BPHL, and which indications are they being tested in?

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