Chitinase
Details
- Name
- Chitinase
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- chiB
- UniProtKB Entry
- Q54276TrEMBL
- Organism
- Serratia marcescens
- NCBI Taxonomy ID
- 615
- Amino acid sequence
>lcl|BSEQ0013047|Chitinase MSTRKAVIGYYFIPTNQINNYTETDTSVVPFPVSNITPAKAKQLTHINFSFLDINSNLEC AWDPATNDAKARDVVNRLTALKAHNPSLRIMFSIGGWYYSNDLGVSHANYVNAVKTPASR AKFAQSCVRIMKDYGFDGVDIDWEYPQAAEVDGFIAALQEIRTLLNQQTITDGRQALPYQ LTIAGAGGAFFLSRYYSKLAQIVAPLDYINLMTYDLAGPWEKVTNHQAALFGDAAGPTFY NALREANLGWSWEELTRAFPSPFSLTVDAAVQQHLMMEGVPSAKIVMGVPFYGRAFKGVS GGNGGQYSSHSTPGEDPYPSTDYWLVGCEECVRDKDPRIASYRQLEQMLQGNYGYQRLWN DKTKTPYLYHAQNGLFVTYDDAESFKYKAKYIKQQQLGGVMFWHLGQDNRNGDLLAALDR YFNAADYDDSQLDMGTGLRYTGVGPGNLPIMTAPAYVPGTTYAQGALVSYQGYVWQTKWG YITSAPGSDSAWLKVGRVA
- Number of residues
- 499
- Molecular Weight
- 55468.96
- Theoretical pI
- 6.32
- GO Classification
- Functionscarbohydrate binding / chitinase activityProcessescarbohydrate metabolic process / chitin catabolic processComponentsextracellular region
- General Function
- Not Available
- Specific Function
- carbohydrate binding
- Pfam Domain Function
- Glyco_hydro_18 (PF00704)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0008303|1500 bp ATGTCCACACGCAAAGCCGTTATTGGGTATTATTTTATTCCAACCAACCAAATCAATAAC TACACCGAGACCGATACGTCCGTCGTGCCATTCCCGGTTTCCAACATTACGCCGGCCAAA GCCAAACAGCTGACGCACATCAACTTCTCGTTCCTGGATATCAACAGCAATCTGGAATGC GCCTGGGATCCGGCCACCAACGACGCCAAGGCGCGCGATGTGGTCAACCGTCTGACCGCG CTCAAAGCGCACAACCCCAGCCTGCGCATCATGTTCTCCATCGGCGGCTGGTACTACTCC AACGATCTGGGCGTGTCGCACGCCAACTATGTCAACGCGGTGAAAACCCCGGCGTCGCGC GCCAAGTTCGCCCAATCCTGCGTGCGCATCATGAAGGATTACGGCTTCGACGGTGTGGAC ATCGACTGGGAGTACCCGCAAGCGGCGGAAGTGGACGGCTTCATCGCCGCGCTGCAGGAG ATCCGCACCTTGCTGAACCAGCAAACCATCACAGACGGCCGCCAGGCGTTGCCGTACCAG TTGACCATCGCCGGCGCCGGCGGCGCCTTCTTCCTGTCGCGCTATTACAGCAAGCTGGCG CAGATCGTCGCGCCGCTCGATTACATCAACCTGATGACCTACGATCTGGCCGGCCCCTGG GAGAAGGTAACCAACCACCAGGCGGCGCTGTTCGGCGACGCGGCCGGGCCGACCTTCTAC AACGCGCTGCGCGAAGCCAATCTGGGCTGGAGCTGGGAAGAGCTGACCCGCGCCTTCCCC AGCCCGTTCAGCCTGACGGTCGACGCCGCCGTGCAGCAACACCTGATGATGGAAGGCGTG CCGAGCGCCAAAATCGTCATGGGCGTGCCCTTCTATGGCCGCGCCTTCAAGGGCGTCAGC GGCGGCAACGGTGGGCAATACAGCAGCCACAGCACGCCGGGCGAAGATCCGTATCCGAGC ACCGACTACTGGCTGGTGGGCTGCGAAGAGTGCGTGCGCGACAAGGATCCGCGCATCGCC TCCTATCGCCAGTTGGAGCAGATGCTGCAGGGCAACTACGGCTATCAGCGGTTGTGGAAC GACAAGACCAAAACCCCTTATCTGTATCATGCGCAGAACGGGCTGTTCGTCACCTATGAC GATGCCGAGAGCTTCAAATACAAAGCGAAGTACATCAAGCAGCAGCAGCTGGGCGGCGTG ATGTTCTGGCATCTGGGGCAAGACAACCGCAACGGCGATCTGCTGGCCGCGCTGGATCGC TATTTCAACGCCGCGGACTACGACGACAGCCAGCTGGATATGGGCACCGGGCTGCGCTAC ACCGGCGTCGGCCCCGGCAACCTGCCTATCATGACCGCGCCGGCCTATGTGCCGGGCACC ACTTACGCGCAGGGCGCGCTGGTGTCCTACCAGGGCTACGTCTGGCAGACCAAGTGGGGT TACATCACCTCTGCACCGGGTTCAGACAGCGCCTGGCTGAAGGTGGGCCGCGTAGCGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q54276 UniProtKB Entry Name Q54276_SERMA GenBank Protein ID 677861 GenBank Gene ID Z36295 PDB ID(s) 1E15, 1E6P, 1E6R, 1E6Z, 1GPF, 1UR8, 1UR9, 1W1P, 1W1T, 1W1V, 1W1Y - General References
- van Aalten DM, Synstad B, Brurberg MB, Hough E, Riise BW, Eijsink VG, Wierenga RK: Structure of a two-domain chitotriosidase from Serratia marcescens at 1.9-A resolution. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5842-7. [Article]
- van Aalten DM, Komander D, Synstad B, Gaseidnes S, Peter MG, Eijsink VG: Structural insights into the catalytic mechanism of a family 18 exo-chitinase. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):8979-84. [Article]
- Tabudravu JN, Eijsink VG, Gooday GW, Jaspars M, Komander D, Legg M, Synstad B, van Aalten DM: Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax. Bioorg Med Chem. 2002 Apr;10(4):1123-8. [Article]
- Vaaje-Kolstad G, Vasella A, Peter MG, Netter C, Houston DR, Westereng B, Synstad B, Eijsink VG, van Aalten DM: Interactions of a family 18 chitinase with the designed inhibitor HM508 and its degradation product, chitobiono-delta-lactone. J Biol Chem. 2004 Jan 30;279(5):3612-9. Epub 2003 Nov 3. [Article]
- Houston DR, Synstad B, Eijsink VG, Stark MJ, Eggleston IM, van Aalten DM: Structure-based exploration of cyclic dipeptide chitinase inhibitors. J Med Chem. 2004 Nov 4;47(23):5713-20. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details (3s,8ar)-3-(4-Hydroxybenzyl)Hexahydropyrrolo[1,2-a]Pyrazine-1,4-Dione experimental unknown target Details