Mediator of RNA polymerase II transcription subunit 1

BE0004382ProteinHumansMED1

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. It is acted on by 1 drug in DrugBank.

Gene name
MED1
UniProtKB entry
Q15648Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,581 residues · 168,477 Da
Also known as
Activator-recruited cofactor 205 kDa component · ARC205 · CRSP1 · CRSP200 · DRIP205

Resolves to

Protein
UniProtQ15648UniProt nameMED1_HUMAN
Gene
HGNCHGNC:9234NCBI Gene5469GenBank2765322GeneCardsMED1
Pharmacology
KEGGhsa:5469
Structure
PDB1RJKPDB1RK3PDB1RKG
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
33GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
41+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Mediator of RNA polymerase II transcription subunit 1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In