Small conductance calcium-activated potassium channel protein 3

BE0004427ProteinHumansKCNN3

Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:12808432, PubMed:20562108, PubMed:31155282, PubMed:36502918). It is acted on by 5 drugs in DrugBank.

Gene name
KCNN3
UniProtKB entry
Q9UGI6Swiss-Prot
Cellular location
Cell membrane
Residues / weight
731 residues · 81,385 Da
Also known as
K3 · KCa2.3 · SK3 · SKCa 3 · SKCa3

Resolves to

Protein
UniProtQ9UGI6UniProt nameKCNN3_HUMAN
Gene
HGNCHGNC:6292NCBI Gene3782GenBank3309531GeneCardsKCNN3
Pharmacology
IUPHAR/GtoPdb383KEGGhsa:3782
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Small conductance calcium-activated potassium channel protein 3, how selective are they, and which programs against it are still in active trials?

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