Oxygen-insensitive NADPH nitroreductase

BE0004435ProteinHelicobacter pylori (strain ATCC 700392 / 26695)rdxA

Reduction of a variety of nitroaromatic compounds using NADPH as source of reducing equivalents; two electrons are transferred (By similarity). It is acted on by 1 drug in DrugBank.

Gene name: rdxA
UniProtKB entry: O25608Swiss-Prot
Residues / weight: 210 residues · 24,068 Da
Also known as: 1.-.-.-

Resolves to

Protein

UniProtO25608UniProt nameRDXA_HELPY

Gene

NCBI Gene899487

Pharmacology

KEGGheo:C694_04915

Structure

PDB3QDL

Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action

2GO termsFunction, process and component, as structured annotations

1Pfam domainDomain architecture mapped to Pfam families and clans

8+ReferencesStructured and connected to the statements they support

Which approved drugs act on Oxygen-insensitive NADPH nitroreductase, how selective are they, and which programs against it are still in active trials?

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