Heparan sulfate glucosamine 3-O-sulfotransferase 1

BE0004436ProteinHumansHS3ST1

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:8900198, PubMed:9346953, PubMed:9988768). It is acted on by 1 drug in DrugBank.

Gene name
HS3ST1
UniProtKB entry
O14792Swiss-Prot
Cellular location
Golgi apparatus lumen
Residues / weight
307 residues · 35,773 Da
Also known as
2.8.2.23 · 3-OST-1 · 3OST · 3OST1 · h3-OST-1

Resolves to

Protein
UniProtO14792UniProt nameHS3S1_HUMAN
Gene
HGNCHGNC:5194NCBI Gene9957GeneCardsHS3ST1
Pharmacology
KEGGhsa:9957
Structure
PDB1ZRH
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Heparan sulfate glucosamine 3-O-sulfotransferase 1, and which indications are they being tested in?

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