Type II inositol 1,4,5-trisphosphate 5-phosphatase

BE0004437ProteinHumansINPP5B

Regulates phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) cellular levels by cleaving the phosphate at the 5-position producing PtdIns(4)P. It is acted on by 1 drug in DrugBank.

Gene name
INPP5B
UniProtKB entry
P32019Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
993 residues · 112,851 Da
Also known as
3.1.3.36 · 3.1.3.56 · 5PTase · 75 kDa inositol polyphosphate-5-phosphatase · OCRL2

Resolves to

Protein
UniProtP32019UniProt nameI5P2_HUMAN
Gene
HGNCHGNC:6077NCBI Gene3633GeneCardsINPP5B
Pharmacology
KEGGhsa:3633
Structure
PDB3MTCPDB3N9VPDB4CML
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Type II inositol 1,4,5-trisphosphate 5-phosphatase, and which indications are they being tested in?

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