Hypocretin neuropeptide precursor

BE0004439ProteinHumansHCRT

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. It is acted on by 1 drug in DrugBank.

Gene name
HCRT
UniProtKB entry
O43612Swiss-Prot
Cellular location
Rough endoplasmic reticulum
Residues / weight
131 residues · 13,363 Da
Also known as
Hcrt · Hypocretin · Orexin precursor · OX · PPORX

Resolves to

Protein
UniProtO43612UniProt nameOREX_HUMAN
Gene
HGNCHGNC:4847NCBI Gene3060GeneCardsHCRT
Pharmacology
KEGGhsa:3060
Structure
PDB1CQ0PDB1R02PDB1UVQ
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hypocretin neuropeptide precursor, how selective are they, and which programs against it are still in active trials?

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