Tartrate-resistant acid phosphatase type 5

BE0004487ProteinHumansACP5

Functions as a binuclear Fe(III)-Fe(II) acid phosphatase that hydrolyzes phosphate esters to alcohols and phosphate under acidic conditions (PubMed:1477968, PubMed:2775236). It is acted on by 1 drug in DrugBank.

Gene name
ACP5
UniProtKB entry
P13686Swiss-Prot
Cellular location
Lysosome
Residues / weight
325 residues · 36,598 Da
Also known as
3.1.3.2 · Purple acid phosphatase · Tartrate-resistant acid ATPase · TR-AP · TRAP

Resolves to

Protein
UniProtP13686UniProt namePPA5_HUMAN
Gene
HGNCHGNC:124NCBI Gene54GeneCardsACP5
Pharmacology
KEGGhsa:54
Structure
PDB1WARPDB2BQ8
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Tartrate-resistant acid phosphatase type 5, and which indications are they being tested in?

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