Cation-dependent mannose-6-phosphate receptor

BE0004494ProteinHumansM6PR

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. It is acted on by 5 drugs in DrugBank.

Gene name
M6PR
UniProtKB entry
P20645Swiss-Prot
Cellular location
Lysosome membrane
Residues / weight
277 residues · 30,993 Da
Also known as
46 kDa mannose 6-phosphate receptor · CD Man-6-P receptor · CD-MPR · MPR 46 · MPR46

Resolves to

Protein
UniProtP20645UniProt nameMPRD_HUMAN
Gene
HGNCHGNC:6752NCBI Gene4074GeneCardsM6PR
Pharmacology
KEGGhsa:4074
Structure
PDB1JUQ
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cation-dependent mannose-6-phosphate receptor, how selective are they, and which programs against it are still in active trials?

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