Enoyl-CoA hydratase, mitochondrial

BE0004500ProteinHumansECHS1

Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding (3S)-3hydroxyacyl-CoA species through addition of a water molecule to the double bond (PubMed:25125611, PubMed:26251176). It is acted on by 5 drugs in DrugBank.

Gene name
ECHS1
UniProtKB entry
P30084Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
290 residues · 31,387 Da
Also known as
4.2.1.17 · 5.3.3.8 · ECHS1 · Enoyl-CoA hydratase 1 · mECH

Resolves to

Protein
UniProtP30084UniProt nameECHM_HUMAN
Gene
HGNCHGNC:3151NCBI Gene1892GeneCardsECHS1
Pharmacology
KEGGhsa:1892
Structure
PDB2HW5PDB8ZRUPDB8ZRV
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Enoyl-CoA hydratase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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