Hepatocyte nuclear factor 1-alpha

BE0004514ProteinHumansHNF1A

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). It is acted on by 2 drugs in DrugBank.

Gene name
HNF1A
UniProtKB entry
P20823Swiss-Prot
Cellular location
Nucleus
Residues / weight
631 residues · 67,386 Da
Also known as
HNF-1-alpha · HNF-1A · LFB1 · Liver-specific transcription factor LF-B1 · TCF-1

Resolves to

Protein
UniProtP20823UniProt nameHNF1A_HUMAN
Gene
HGNCHGNC:11621NCBI Gene6927GeneCardsHNF1A
Pharmacology
KEGGhsa:6927
Structure
PDB1IC8PDB2GYPPDB8PI7
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
8GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
35+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Hepatocyte nuclear factor 1-alpha, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In