Poly(A) polymerase alpha

BE0004515ProteinHumansPAPOLA

Polymerase that creates the 3'-poly(A) tail of mRNA's. It is acted on by 4 drugs in DrugBank.

Gene name
PAPOLA
UniProtKB entry
P51003Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
745 residues · 82,842 Da
Also known as
2.7.7.19 · PAP · PAP-alpha · Polynucleotide adenylyltransferase alpha

Resolves to

Protein
UniProtP51003UniProt namePAPOA_HUMAN
Gene
HGNCHGNC:14981NCBI Gene10914GeneCardsPAPOLA
Pharmacology
KEGGhsa:10914
Structure
PDB8R8R
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Poly(A) polymerase alpha, and which indications are they being tested in?

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