Bile salt-activated lipase

BE0004523ProteinHumansCEL

Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs) (PubMed:10220579, PubMed:27509211, PubMed:27650499, PubMed:8471055). It is acted on by 5 drugs in DrugBank.

Gene name
CEL
UniProtKB entry
P19835Swiss-Prot
Cellular location
Secreted
Residues / weight
753 residues · 79,321 Da
Also known as
3.1.1.13 · 3.1.1.3 · 3.1.1.6 · BAL · Bile salt-stimulated lipase

Resolves to

Protein
UniProtP19835UniProt nameCEL_HUMAN
Gene
HGNCHGNC:1848NCBI Gene1056GeneCardsCEL
Pharmacology
KEGGhsa:1056
Structure
PDB1F6WPDB1JMYPDB6H0T
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bile salt-activated lipase, how selective are they, and which programs against it are still in active trials?

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