V-type proton ATPase subunit C 1

BE0004525ProteinHumansATP6V1C1

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). It is acted on by 2 drugs in DrugBank.

Gene name
ATP6V1C1
UniProtKB entry
P21283Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Residues / weight
382 residues · 43,941 Da
Also known as
ATP6C · ATP6D · V-ATPase subunit C 1 · Vacuolar proton pump subunit C 1 · VATC

Resolves to

Protein
UniProtP21283UniProt nameVATC1_HUMAN
Gene
HGNCHGNC:856NCBI Gene528GeneCardsATP6V1C1
Pharmacology
KEGGhsa:528
Structure
PDB6WM2PDB6WM3PDB6WM4
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on V-type proton ATPase subunit C 1, how selective are they, and which programs against it are still in active trials?

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