Follistatin

BE0004526ProteinHumansFST

Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs) (PubMed:11279126, PubMed:16482217, PubMed:18535106). It is acted on by 1 drug in DrugBank.

Gene name
FST
UniProtKB entry
P19883Swiss-Prot
Cellular location
Secreted
Residues / weight
344 residues · 38,007 Da
Also known as
Activin-binding protein · FS

Resolves to

Protein
UniProtP19883UniProt nameFST_HUMAN
Gene
HGNCHGNC:3971NCBI Gene10468GeneCardsFST
Pharmacology
KEGGhsa:10468
Structure
PDB2B0UPDB2P6APDB3HH2
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Follistatin, and which indications are they being tested in?

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