Elongation factor 1-alpha 1

BE0004528ProteinHumansEEF1A1

Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). It is acted on by 7 drugs in DrugBank.

Gene name
EEF1A1
UniProtKB entry
P68104Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
462 residues · 50,141 Da
Also known as
3.6.5.- · EEF1A · eEF1A-1 · EF-1-alpha-1 · EF-Tu

Resolves to

Protein
UniProtP68104UniProt nameEF1A1_HUMAN
Gene
HGNCHGNC:3189NCBI Gene1915GeneCardsEEF1A1
Pharmacology
KEGGhsa:1915
Structure
PDB3C5JPDB6ZMOPDB8G60
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
19GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
25+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Elongation factor 1-alpha 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In