Ubiquitin-conjugating enzyme E2 D2

BE0004530ProteinHumansUBE2D2

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:10329681, PubMed:18042044, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694, PubMed:26475854, PubMed:28322253). It is acted on by 1 drug in DrugBank.

Gene name
UBE2D2
UniProtKB entry
P62837Swiss-Prot
Residues / weight
147 residues · 16,735 Da
Also known as
(E3-independent) E2 ubiquitin-conjugating enzyme D2 · 2.3.2.23 · E2 ubiquitin-conjugating enzyme D2 · p53-regulated ubiquitin-conjugating enzyme 1 · PUBC1

Resolves to

Protein
UniProtP62837UniProt nameUB2D2_HUMAN
Gene
HGNCHGNC:12475NCBI Gene7322GeneCardsUBE2D2
Pharmacology
KEGGhsa:7322
Structure
PDB1UR6PDB1W4UPDB2CLW
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Ubiquitin-conjugating enzyme E2 D2, and which indications are they being tested in?

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