Adenylate kinase 8
Details
- Name
- Adenylate kinase 8
- Kind
- protein
- Synonyms
- 2.7.4.3
- 2.7.4.6
- AK 8
- ATP-AMP transphosphorylase 8
- C9orf98
- Gene Name
- AK8
- UniProtKB Entry
- Q96MA6Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0009457|Adenylate kinase 8 MDATIAPHRIPPEMPQYGEENHIFELMQNMLEQLLIHQPEDPIPFMIQHLHRDNDNVPRI VILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTVPSALLVQ LIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRI DPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVI SADQPCVDVFYQALTYVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCG QLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLD QAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQ NPKDAEEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEYIESGIINPLPKKIP
- Number of residues
- 479
- Molecular Weight
- 54925.01
- Theoretical pI
- Not Available
- GO Classification
- Functions(d)CMP kinase activity / AMP bindingComponents9+2 motile cilium / axoneme / cytoplasm / sperm flagellum
- General Function
- Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity
- Specific Function
- (d)CMP kinase activity
- Pfam Domain Function
- ADK (PF00406)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm, cytosol
- Gene sequence
>lcl|BSEQ0017465|Adenylate kinase 8 (AK8) ATGGACGCCACTATCGCCCCGCACCGTATCCCCCCCGAGATGCCCCAGTACGGGGAGGAG AACCACATCTTCGAGTTGATGCAGAACATGCTGGAGCAACTCCTGATCCACCAGCCCGAA GATCCCATCCCCTTCATGATCCAGCACTTGCATAGAGACAACGACAATGTGCCCAGGATT GTAATATTAGGTCCACCCGCCTCAGGGAAAACAACAATAGCAATGTGGCTCTGCAAACAT CTGAACAGCAGTCTCCTCACCCTGGAGAACCTGATCTTAAATGAGTTTTCCTATACGGCC ACCGAAGCCAGAAGGCTTTATCTGCAAAGGAAGACAGTTCCCAGCGCGCTGCTCGTCCAG CTGATTCAGGAACGCCTGGCTGAAGAGGATTGCATCAAGCAGGGCTGGATTCTGGATGGC ATCCCTGAGACGCGTGAGCAGGCTCTGAGGATCCAGACCCTGGGGATCACACCCAGACAC GTCATTGTGCTGAGTGCTCCAGACACGGTCCTGATCGAGAGAAACTTGGGGAAGAGAATC GACCCTCAAACTGGAGAGATTTATCACACCACCTTTGACTGGCCACCCGAATCTGAAATC CAGAACCGTCTCATGGTGCCAGAGGACATCTCAGAGCTGGAGACGGCTCAGAAACTGCTG GAGTATCATAGGAACATCGTCAGGGTCATTCCCTCCTACCCCAAAATCCTCAAAGTCATC AGTGCTGACCAGCCATGTGTGGACGTCTTCTACCAGGCTCTGACCTATGTCCAAAGCAAC CATCGTACTAATGCCCCGTTCACCCCGAGGGTGCTGCTGCTCGGGCCTGTGGGCAGTGGG AAAAGTCTGCAGGCCGCCCTCCTGGCCCAGAAATACAGGCTTGTCAATGTCTGCTGTGGG CAACTGCTGAAAGAGGCTGTGGCAGATAGGACCACGTTTGGCGAGCTCATCCAGCCCTTC TTTGAAAAGGAGATGGCAGTTCCTGACAGCCTCCTCATGAAGGTGCTGAGCCAGCGCCTG GACCAGCAGGACTGCATCCAGAAAGGCTGGGTGCTACACGGCGTCCCGCGGGACCTCGAC CAGGCACACCTGCTGAACCGCCTGGGCTACAATCCCAACAGGGTGTTTTTCCTGAATGTG CCATTTGATTCCATCATGGAGCGGCTGACTCTGAGAAGAATTGATCCAGTCACTGGGGAA AGGTACCACCTCATGTACAAGCCACCTCCCACCATGGAGATCCAGGCTCGCCTCCTGCAG AACCCAAAGGATGCTGAAGAGCAGGTCAAGCTGAAAATGGACCTGTTCTACAGGAACTCA GCTGACTTGGAGCAGTTGTATGGGTCGGCCATCACCCTCAATGGGGACCAGGACCCATAC ACAGTCTTCGAATACATCGAGAGTGGGATCATTAATCCCCTGCCCAAGAAAATCCCCTGA
- Chromosome Location
- 9
- Locus
- 9q34.13
- External Identifiers
Resource Link UniProtKB ID Q96MA6 UniProtKB Entry Name KAD8_HUMAN GeneCard ID AK8 HGNC ID HGNC:26526 KEGG ID hsa:158067 NCBI Gene ID 158067 - General References
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- Panayiotou C, Solaroli N, Xu Y, Johansson M, Karlsson A: The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes. Biochem J. 2011 Feb 1;433(3):527-34. doi: 10.1042/BJ20101443. [Article]
- Amiri M, Conserva F, Panayiotou C, Karlsson A, Solaroli N: The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. Int J Biochem Cell Biol. 2013 May;45(5):925-31. doi: 10.1016/j.biocel.2013.02.004. Epub 2013 Feb 14. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Bis(Adenosine)-5'-Pentaphosphate experimental unknown target Details