Serine protease inhibitor Kazal-type 6
Details
- Name
- Serine protease inhibitor Kazal-type 6
- Kind
- protein
- Synonyms
- Kallikrein inhibitor
- Gene Name
- SPINK6
- UniProtKB Entry
- Q6UWN8Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0017470|Serine protease inhibitor Kazal-type 6 MKLSGMFLLLSLALFCFLTGVFSQGGQVDCGEFQDPKVYCTRESNPHCGSDGQTYGNKCA FCKAIVKSGGKISLKHPGKC
- Number of residues
- 80
- Molecular Weight
- 8584.965
- Theoretical pI
- Not Available
- GO Classification
- Not Available
- General Function
- Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8
- Specific Function
- serine-type endopeptidase inhibitor activity
- Pfam Domain Function
- Kazal_1 (PF00050)
- Signal Regions
- 1-23
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0017471|Serine protease inhibitor Kazal-type 6 (SPINK6) ATGAAACTGTCAGGCATGTTTCTGCTCCTCTCTCTGGCTCTTTTCTGCTTTTTAACAGGT GTCTTCAGTCAGGGAGGACAGGTTGACTGTGGTGAGTTCCAGGACCCCAAGGTCTACTGC ACTCGGGAATCTAACCCACACTGTGGCTCTGATGGCCAGACATATGGCAATAAATGTGCC TTCTGTAAGGCCATAGTGAAAAGTGGTGGAAAGATTAGCCTAAAGCATCCTGGAAAATGC TGA
- Chromosome Location
- 5
- Locus
- 5q32
- External Identifiers
Resource Link UniProtKB ID Q6UWN8 UniProtKB Entry Name ISK6_HUMAN GeneCard ID SPINK6 HGNC ID HGNC:29486 PDB ID(s) 2N52 KEGG ID hsa:404203 NCBI Gene ID 404203 - General References
- Meyer-Hoffert U, Wu Z, Kantyka T, Fischer J, Latendorf T, Hansmann B, Bartels J, He Y, Glaser R, Schroder JM: Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases. J Biol Chem. 2010 Oct 15;285(42):32174-81. doi: 10.1074/jbc.M109.091850. Epub 2010 Jul 28. [Article]
- Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Zhang Z, Henzel WJ: Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. 2004 Oct;13(10):2819-24. Epub 2004 Aug 31. [Article]
- Kantyka T, Fischer J, Wu Z, Declercq W, Reiss K, Schroder JM, Meyer-Hoffert U: Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6. Peptides. 2011 Jun;32(6):1187-92. doi: 10.1016/j.peptides.2011.03.009. Epub 2011 Mar 23. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Leucine - Reduced Carbonyl experimental unknown target Details