Fructose-bisphosphate aldolase B

BE0004565ProteinHumansALDOB

Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. It is acted on by 3 drugs in DrugBank.

Gene name
ALDOB
UniProtKB entry
P05062Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
364 residues · 39,473 Da
Also known as
4.1.2.13 · ALDB · Liver-type aldolase

Resolves to

Protein
UniProtP05062UniProt nameALDOB_HUMAN
Gene
HGNCHGNC:417NCBI Gene229GeneCardsALDOB
Pharmacology
KEGGhsa:229
Structure
PDB1QO5PDB1XDLPDB1XDM
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Fructose-bisphosphate aldolase B, and which indications are they being tested in?

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