Carboxypeptidase D
Details
- Name
- Carboxypeptidase D
- Kind
- protein
- Synonyms
- 3.4.17.22
- gp180
- Metallocarboxypeptidase D
- Gene Name
- CPD
- UniProtKB Entry
- O75976Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0009489|Carboxypeptidase D MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYH EEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPD AAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLP SLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRA LIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHP IMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPAS QLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFY RLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTV AIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYV MEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRI HLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMK SYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPC KNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQ NRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTY KITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTK EFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLG QSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPA VTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAII ENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSC PNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADN KRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNII AIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIW CICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH
- Number of residues
- 1380
- Molecular Weight
- 152929.865
- Theoretical pI
- Not Available
- GO Classification
- Componentsplasma membrane
- General Function
- Not Available
- Specific Function
- Metallocarboxypeptidase activity
- Pfam Domain Function
- Signal Regions
- 1-31
- Transmembrane Regions
- 1300-1320
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0019599|Carboxypeptidase D (CPD) ATGAGGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTT GATGATTCTCCAGAACATAAGGCCACTGGAATCTATAGCAAAACCTCAGATGATGAAGTA TTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCCATAATGAAAACTGGTGAGCCT CATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGG TATGATGTGGAAGGTGGTATGCAAGATTACAATTATGTGTGGGCCAACTGTTTTGAGATC ACATTAGAACTGTCTTGTTGCAAGTACCCACCTGCTTCACAGCTTCGACAGGAATGGGAG AACAATCGTGAGTCTTTGATCACATTGATTGAAAAGGTTCACATTGGAGTGAAAGGATTT GTTAAAGATTCCATAACAGGATCTGGGTTAGAGAATGCAACCATCTCAGTGGCTGGTATT AATCATAATATCACAACAGGCAGATTTGGTGATTTCTACCGATTACTTGTTCCTGGAACT TACAACCTTACAGTAGTTTTAACTGGGTATATGCCATTGACTGTTACTAATGTAGTGGTG AAAGAAGGACCAGCCACAGAGGTGGATTTTTCTCTTAGGCCAACTGTAACTTCAGTAATC CCTGACACGACAGAGGCTGTATCAACTGCTAGCACAGTTGCTATACCTAATATTCTTTCT GGAACATCATCCTCCTACCAGCCAATTCAGCCAAAGGACTTTCACCACCACCATTTCCCT GATATGGAAATCTTCTTGAGAAGGTTTGCCAATGAATATCCTAACATTACCCGGCTTTAT TCCTTGGGAAAATCAGTAGAGTCAAGAGAACTTTATGTGATGGAGATATCTGATAATCCG GGTGTCCATGAACCAGGTGAACCAGAATTTAAGTACATTGGAAATATGCATGGAAATGAA GTGGTTGGAAGAGAACTGCTGTTGAACCTCATAGAATACCTTTGTAAGAACTTTGGAACA GACCCTGAAGTCACAGATTTGGTTCATAACACTAGAATTCACCTTATGCCATCCATGAAT CCTGATGGGTATGAAAAGTCCCAGGAAGGAGATTCAATAAGTGTAATTGGCAGAAACAAC AGCAACAACTTTGACCTGAACCGAAATTTCCCAGACCAGTTTGTTCAGATCACAGATCCT ACGCAACCAGAAACTATTGCTGTAATGAGCTGGATGAAGTCCTATCCATTTGTACTTTCA GCAAACCTGCATGGAGGTTCTTTGGTGGTTAACTACCCTTTTGATGATGATGAACAAGGA CTTGCCACATATAGTAAATCACCAGATGATGCTGTGTTCCAACAAATAGCACTTTCTTAT TCCAAGGAAAATTCCCAGATGTTTCAAGGTAGACCTTGCAAGAATATGTATCCTAATGAA TATTTTCCTCATGGAATAACAAATGGAGCTAGTTGGTATAATGTGCCAGGAGGAATGCAG GACTGGAACTATTTACAAACAAATTGCTTTGAAGTGACTATTGAACTAGGTTGTGTGAAA TATCCACTTGAGAAAGAGCTGCCAAACTTTTGGGAACAGAATCGAAGATCACTAATCCAG TTTATGAAACAGGTTCATCAGGGCGTCAGAGGATTTGTTCTAGATGCCACAGATGGCAGG GGTATATTAAATGCCACCATTAGTGTTGCTGAGATTAATCACCCAGTGACTACTTACAAA ACTGGAGATTACTGGCGTCTCTTGGTTCCAGGAACTTATAAAATCACAGCATCTGCTCGA GGGTATAATCCAGTTACCAAGAATGTGACTGTCAAGAGTGAAGGCGCTATTCAGGTCAAC TTCACACTTGTTCGATCCTCAACAGATTCAAACAATGAATCAAAGAAAGGAAAAGGGGCT AGCAGCAGCACCAATGATGCCAGTGATCCAACTACTAAAGAGTTTGAAACTTTAATTAAA GACCTTTCAGCGGAGAATGGTTTGGAAAGCCTCATGTTACGCTCCTCCTCAAATCTGGCT CTGGCTCTTTATCGATACCATTCCTACAAAGACTTATCAGAGTTTCTGAGAGGACTTGTA ATGAACTATCCACATATTACAAATCTTACCAATTTGGGACAGAGCACTGAATATCGTCAC ATTTGGTCCCTTGAAATCTCCAATAAGCCCAATGTATCTGAGCCTGAAGAACCAAAGATT CGTTTTGTTGCTGGTATCCATGGAAATGCGCCAGTTGGAACTGAACTGCTTTTGGCTCTG GCAGAATTTCTCTGCCTGAACTACAAAAAGAACCCAGCTGTTACCCAATTGGTTGACAGG ACTAGGATTGTGATTGTCCCTTCTCTAAATCCAGATGGGCGAGAGAGAGCTCAAGAGAAA GACTGTACTTCAAAAATAGGACAAACAAATGCTCGTGGCAAAGATTTGGATACAGACTTC ACAAATAATGCCTCCCAACCTGAGACCAAAGCCATCATTGAAAATTTGATTCAAAAACAG GACTTTAGTCTTTCTGTTGCCTTAGATGGTGGTTCCATGCTGGTCACATATCCTTATGAC AAGCCAGTACAGACAGTGGAAAATAAAGAGACTCTGAAGCATTTGGCATCTCTTTATGCA AATAATCATCCATCCATGCACATGGGTCAGCCCAGTTGCCCAAATAAATCAGATGAGAAT ATTCCAGGAGGAGTAATGCGTGGAGCAGAATGGCATAGTCACCTGGGCAGCATGAAGGAT TATAGTGTCACCTATGGCCATTGTCCGGAAATCACAGTATACACAAGCTGCTGTTACTTT CCTAGTGCTGCACGACTCCCTTCCTTGTGGGCAGACAATAAGAGATCTCTTCTTAGTATG TTAGTGGAGGTTCACAAGGGAGTTCATGGATTTGTTAAAGATAAGACTGGAAAGCCAATC TCTAAAGCAGTCATTGTACTTAATGAAGGAATAAAGGTACAAACAAAAGAGGGAGGTTAT TTCCATGTACTCTTAGCGCCAGGTGTCCATAACATTATTGCCATCGCTGATGGGTACCAG CAACAACATTCACAGGTCTTTGTGCATCATGATGCAGCTAGTTCTGTGGTGATAGTCTTT GACACAGATAACCGGATATTTGGTTTGCCAAGGGAGCTTGTGGTAACTGTATCAGGTGCT ACTATGTCGGCATTGATCCTAACAGCTTGCATTATTTGGTGCATCTGCTCAATCAAGTCT AATAGACACAAGGATGGCTTTCATCGGCTCAGGCAGCATCATGATGAGTATGAAGATGAA ATTCGCATGATGTCTACCGGCTCCAAGAAGTCCCTCCTAAGCCATGAGTTCCAGGATGAA ACAGACACTGAAGAGGAAACATTATATTCTAGCAAACATTGA
- Chromosome Location
- 17
- Locus
- 17q11.2
- External Identifiers
Resource Link UniProtKB ID O75976 UniProtKB Entry Name CBPD_HUMAN GeneCard ID CPD HGNC ID HGNC:2301 PDB ID(s) 5AQ0 KEGG ID hsa:1362 NCBI Gene ID 1362 - General References
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- Tan F, Rehli M, Krause SW, Skidgel RA: Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains. Biochem J. 1997 Oct 1;327 ( Pt 1):81-7. [Article]
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- McGwire GB, Tan F, Michel B, Rehli M, Skidgel RA: Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein. Life Sci. 1997;60(10):715-24. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Guanidinoethylmercaptosuccinic acid experimental unknown target Details