Branched-chain alpha-ketoacid dehydrogenase kinase

BE0004571ProteinHumansBCKDK

Serine/threonine-protein kinase component of macronutrients metabolism. It is acted on by 1 drug in DrugBank.

Gene name
BCKDK
UniProtKB entry
O14874Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
412 residues · 46,360 Da
Also known as
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial · 2.7.11.1 · BCKDH kinase · BCKDHKIN · BDK

Resolves to

Protein
UniProtO14874UniProt nameBCKD_HUMAN
Gene
HGNCHGNC:16902NCBI Gene10295GeneCardsBCKDK
Pharmacology
KEGGhsa:10295
Structure
PDB7ZPEPDB8F5FPDB8F5J
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Branched-chain alpha-ketoacid dehydrogenase kinase, and which indications are they being tested in?

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