2'-5'-oligoadenylate synthase 1

BE0004585ProteinHumansOAS1

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:34581622). It is acted on by 1 drug in DrugBank.

Gene name
OAS1
UniProtKB entry
P00973Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
400 residues · 46,028 Da
Also known as
(2-5')oligo(A) synthase 1 · 2-5A synthase 1 · 2.7.7.84 · E18/E16 · OIAS

Resolves to

Protein
UniProtP00973UniProt nameOAS1_HUMAN
Gene
HGNCHGNC:8086NCBI Gene4938GeneCardsOAS1
Pharmacology
KEGGhsa:4938
Structure
PDB4IG8
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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20GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2'-5'-oligoadenylate synthase 1, and which indications are they being tested in?

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