Kinesin-like protein KIF2C

BE0004622ProteinHumansKIF2C

In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). It is acted on by 1 drug in DrugBank.

Gene name
KIF2C
UniProtKB entry
Q99661Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
725 residues · 81,312 Da
Also known as
Kinesin-like protein 6 · KNSL6 · MCAK · Mitotic centromere-associated kinesin

Resolves to

Protein
UniProtQ99661UniProt nameKIF2C_HUMAN
Gene
HGNCHGNC:6393NCBI Gene11004GeneCardsKIF2C
Pharmacology
KEGGhsa:11004
Structure
PDB2HEHPDB4UBFPDB4Y05
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Kinesin-like protein KIF2C, and which indications are they being tested in?

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