Mannan-binding lectin serine protease 2

BE0004630ProteinHumansMASP2

Precursor of a serum protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11527969,... It is acted on by 2 drugs in DrugBank.

Gene name
MASP2
UniProtKB entry
O00187Swiss-Prot
Cellular location
Secreted
Residues / weight
686 residues · 75,702 Da
Also known as
3.4.21.104 · Mannose-binding protein-associated serine protease 2 · MASP-2 · MBL-associated serine protease 2

Resolves to

Protein
UniProtO00187UniProt nameMASP2_HUMAN
Gene
HGNCHGNC:6902NCBI Gene10747GeneCardsMASP2
Pharmacology
IUPHAR/GtoPdb3336KEGGhsa:10747
Structure
PDB1Q3XPDB1SZBPDB1ZJK
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mannan-binding lectin serine protease 2, how selective are they, and which programs against it are still in active trials?

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