Thymidine kinase 2, mitochondrial

BE0004639ProteinHumansTK2

Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix (PubMed:11687801, PubMed:9989599). It is acted on by 6 drugs in DrugBank.

Gene name
TK2
UniProtKB entry
O00142Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
265 residues · 31,005 Da
Also known as
2.7.1.21 · 2'-deoxyuridine kinase TK2 · Deoxycytidine kinase TK2 · Mt-TK

Resolves to

Protein
UniProtO00142UniProt nameKITM_HUMAN
Gene
HGNCHGNC:11831NCBI Gene7084GeneCardsTK2
Pharmacology
KEGGhsa:7084
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thymidine kinase 2, mitochondrial, how selective are they, and which programs against it are still in active trials?

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