Acetylcholine receptor subunit alpha

BE0004661ProteinHumansCHRNA1

Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. It is acted on by 4 drugs in DrugBank.

Gene name
CHRNA1
UniProtKB entry
P02708Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
457 residues · 51,838 Da
Also known as
ACHRA · CHNRA

Resolves to

Protein
UniProtP02708UniProt nameACHA_HUMAN
Gene
HGNCHGNC:1955NCBI Gene1134GeneCardsCHRNA1
Pharmacology
IUPHAR/GtoPdb462KEGGhsa:1134
Structure
PDB4ZJSPDB5HBTPDB9DMG
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
21GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
24+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Acetylcholine receptor subunit alpha, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In