Carbamoyl-phosphate synthase [ammonia], mitochondrial

BE0004671ProteinHumansCPS1

Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. It is acted on by 2 drugs in DrugBank.

Gene name
CPS1
UniProtKB entry
P31327Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
1,500 residues · 164,938 Da
Also known as
6.3.4.16 · Carbamoyl-phosphate synthetase I · CPSase I

Resolves to

Protein
UniProtP31327UniProt nameCPSM_HUMAN
Gene
HGNCHGNC:2323NCBI Gene1373GeneCardsCPS1
Pharmacology
KEGGhsa:1373
Structure
PDB2YVQPDB4UTRPDB4UTV
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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15GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carbamoyl-phosphate synthase [ammonia], mitochondrial, how selective are they, and which programs against it are still in active trials?

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