Complement C4-A

BE0004685ProteinHumansC4A

Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. It is acted on by 3 drugs in DrugBank.

Gene name
C4A
UniProtKB entry
P0C0L4Swiss-Prot
Cellular location
Secreted
Residues / weight
1,744 residues · 192,784 Da
Also known as
Acidic complement C4 · C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2 · CO4 · CPAMD2

Resolves to

Protein
UniProtP0C0L4UniProt nameCO4A_HUMAN
Gene
HGNCHGNC:1323NCBI Gene721GeneCardsC4A
Pharmacology
KEGGhsa:721
Structure
PDB1HZFPDB5JPMPDB5JPN
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
8GO termsFunction, process and component, as structured annotations
Sign in
11Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
39+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Complement C4-A, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In