A disintegrin and metalloproteinase with thrombospondin motifs 4

BE0004687ProteinHumansADAMTS4

Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). It is acted on by 3 drugs in DrugBank.

Gene name
ADAMTS4
UniProtKB entry
O75173Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
837 residues · 90,196 Da
Also known as
3.4.24.82 · ADAM-TS 4 · ADAM-TS4 · ADAMTS-4 · ADMP-1

Resolves to

Protein
UniProtO75173UniProt nameATS4_HUMAN
Gene
HGNCHGNC:220NCBI Gene9507GeneCardsADAMTS4
Pharmacology
IUPHAR/GtoPdb1677KEGGhsa:9507
Structure
PDB2RJPPDB3B2ZPDB4WK7
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on A disintegrin and metalloproteinase with thrombospondin motifs 4, how selective are they, and which programs against it are still in active trials?

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