Bleomycin hydrolase

BE0004697ProteinHumansBLMH

The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant... It is acted on by 1 drug in DrugBank.

Gene name
BLMH
UniProtKB entry
Q13867Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
455 residues · 52,562 Da
Also known as
3.4.22.40 · BH · BLM hydrolase · BMH

Resolves to

Protein
UniProtQ13867UniProt nameBLMH_HUMAN
Gene
HGNCHGNC:1059NCBI Gene642GeneCardsBLMH
Pharmacology
KEGGhsa:642
Structure
PDB1CB5PDB2CB5PDB7V5L
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bleomycin hydrolase, how selective are they, and which programs against it are still in active trials?

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