SH2B adapter protein 3
Details
- Name
- SH2B adapter protein 3
- Kind
- protein
- Synonyms
- LNK
- Lymphocyte adapter protein
- Lymphocyte-specific adapter protein Lnk
- Signal transduction protein Lnk
- Gene Name
- SH2B3
- UniProtKB Entry
- Q9UQQ2Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0019620|SH2B adapter protein 3 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF DPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA ELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
- Number of residues
- 575
- Molecular Weight
- 63224.45
- Theoretical pI
- Not Available
- GO Classification
- Functionsprotein tyrosine kinase binding / signaling receptor complex adaptor activity / stem cell factor receptor binding / transmembrane receptor protein tyrosine kinase adaptor activityProcessescellular response to chemokine / cellular response to interleukin-3 / erythrocyte development / hematopoietic stem cell differentiation / megakaryocyte development / monocyte homeostasis / negative regulation of cell population proliferation / negative regulation of chemokine-mediated signaling pathway / negative regulation of Kit signaling pathway / negative regulation of MAPK cascade / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of platelet aggregation / negative regulation of receptor signaling pathway via JAK-STAT / negative regulation of receptor signaling pathway via STAT / negative regulation of response to cytokine stimulus / neutrophil homeostasis / thrombopoietin-mediated signaling pathwayComponentsplasma membrane
- General Function
- Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase
- Specific Function
- protein tyrosine kinase binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0019621|SH2B adapter protein 3 (SH2B3) ATGGGATTCCCGGTGCTGTGCCGTGGCTGGAGGAGGACCTGGCCTGGCTGTGCCAGTTGG CTGGGAGCCCCTCCACCCCAGAAGCCCTTGCTCTCACCTCTTCTTCTGAATCATCGTTCT TCGAAGAGTTCAAGGCCCAAGCTACAAGCAGCTTGCTCCAGCATCCAGGAGGTCCGGTGG TGCACACGGCTTGAGATGCCTGACAACCTTTACACCTTTGTGCTGAAGGTGAAGGACCGG ACAGACATCATCTTTGAGGTGGGAGACGAGCAGCAGCTGAATTCATGGATGGCTGAGCTC TCGGAGTGCACAGGCCGAGGGCTGGAGAGCACAGAAGCAGAGATGCATATTCCCTCAGCC CTAGAGCCTAGCACGTCCAGCTCCCCAAGGGGCAGCACAGATTCCCTTAACCAAGGTGCT TCTCCTGGGGGGCTGCTGGACCCGGCCTGCCAGAAGACGGACCATTTCCTGTCCTGCTAC CCCTGGTTCCACGGCCCCATCTCCAGAGTGAAAGCAGCTCAGCTGGTTCAGCTGCAGGGC CCTGATGCTCATGGAGTGTTCCTGGTGCGGCAGAGCGAGACGCGGCGTGGGGAATACGTG CTCACTTTCAACTTTCAGGGGATAGCCAAGCACCTGCGCCTGTCGCTGACAGAGCGGGGC CAGTGCCGTGTGCAGCACCTCCACTTTCCCTCGGTCGTGGACATGCTCCACCACTTCCAG CGCTCGCCCATCCCACTCGAGTGCGGCGCCGCCTGTGATGTCCGGCTCTCCAGCTACGTG GTAGTCGTCTCCCAACCACCAGGTTCCTGCAACACGGTCCTCTTCCCTTTCTCCCTTCCT CACTGGGATTCAGAGTCCCTTCCTCACTGGGGTTCAGAGTTGGGCCTTCCCCACCTTAGT TCTTCTGGCTGTCCCCGGGGGCTCAGCCCAGAGGGTCTCCCAGGGCGATCCTCACCCCCC GAGCAGATCTTCCACCTGGTGCCTTCGCCCGAAGAACTGGCCAACAGCCTGCAGCACCTG GAGCATGAGCCTGTGAATCGAGCCCGGGACTCGGACTACGAAATGGACTCATCCTCCCGG AGCCACCTGCGGGCCATAGACAATCAGTACACACCTCTCTGA
- Chromosome Location
- 12
- Locus
- 12q24.12
- External Identifiers
Resource Link UniProtKB ID Q9UQQ2 UniProtKB Entry Name SH2B3_HUMAN GeneCard ID SH2B3 HGNC ID HGNC:29605 KEGG ID hsa:10019 NCBI Gene ID 10019 - General References
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