Potassium voltage-gated channel subfamily B member 1

BE0004721ProteinHumansKCNB1

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. It is acted on by 2 drugs in DrugBank.

Gene name
KCNB1
UniProtKB entry
Q14721Swiss-Prot
Cellular location
Cell membrane
Residues / weight
858 residues · 95,877 Da
Also known as
Delayed rectifier potassium channel 1 · DRK1 · h-DRK1 · Voltage-gated potassium channel subunit Kv2.1

Resolves to

Protein
UniProtQ14721UniProt nameKCNB1_HUMAN
Gene
HGNCHGNC:6231NCBI Gene3745GeneCardsKCNB1
Pharmacology
IUPHAR/GtoPdb546KEGGhsa:3745
Structure
PDB7RE5PDB7SPDPDB9O10
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Potassium voltage-gated channel subfamily B member 1, how selective are they, and which programs against it are still in active trials?

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